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The only way to guarantee that you will not become infected with an STI is to abstain from sexual activity. If you are having sex, you significantly reduce your chances of becoming infected by using a condom every time you have intercourse (oral, vaginal or anal). Open communication between sexual partners is also very effective in preventing the spread of STIs; do not assume that your partner does not have an STI. Remember, most infections do not show any symptoms. Get tested to be sure! The fewer sexual partners you have, the less risk you run of becoming infected.
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